TheraProteins is the leading supplier of oligosaccharide reference standards for the Quality Release Testing of recombinant pharmaceutical glycoproteins and for glycobiology research  

TheraProteins offers the world’s largest number of N-glycans for use in:

• Quality Control-testing of recombinant glycoprotein pharmaceuticals

•  In production process optimization / product quality optimization  

•  In lot-to-lot consistency/stability studies of drug substance and drug product 

•  In the developmental phase or final stage of biotechnological processes. 

•  Market release or glycoprotein pharrmaceuticals

 We deliver 10, 20 or 100 µg quantities of highest purity (>96%) individual N-linked oligosaccharides suitable for cGMP compliant testing of pharmaceutical glycoproteins via glycan mapping procedures (HPAEC-PAD, mass spectrometry, labeling procedures etc).

?  Up to 10 mg quantities of many of our oligosaccharide structures are available upon request.

?  TheraProteins also supplies oligosaccharide libraries, e.g., for recombinant antibody glycosylation mapping (> 30 different glycan structures found in recombinant antibodies from CHO cells), cell lines and serum proteins TheraProteins also offers custom preparation of quantified glycan structure mixtures/libraries (quantified by a cGMP-certified laboratory according to a validated SOP used for GMP compliant release assays).

 ?  N-glycan structures are isolated from recombinant cell lines (CHO, BHK and HEK cells) or culture supernatants thereof. A combined approach using specific glycosidases and glycosyltransferases is used for preparations of some of the structures.

?  Purity is checked by HPAEC-PAD procedures and by ESI-MS or MALDI/TOF-MS and structural identity is confirmed by NMR analysis and/or MS-MS of the basic structures.

?  Apart from the N-glycans listed in the catalogue, TheraProteins offers also custom preparation of oligosaccharide structures for clients from the pharmaceutical industry and for research laboratories.