ABOUT US

TheraProteins is our passion


TheraProteins is the leading supplier of oligosaccharide reference standards for the Quality Release Testing of recombinant pharmaceutical glycoproteins and for glycobiology research

 
WE OFFER

the worlds largest number of N-glycans


1

Quality Control

Quality Control-testing of recombinant glycoprotein pharmaceuticals


2

Production Optimization

In production process optimization / product quality optimization


3

Consistency and Stability

In lot-to-lot consistency/stability studies of drug substance and drug product


5

Release

Market release or glycoprotein pharrmaceuticals


4

Biothecnological Processes

In the developmental phase or final stage of biotechnological processes.

TheraProteins

what we can do for you.

We deliver 10, 20 or 100ug quantities of highest purity (>96%) individual N-linked oligosaccharides suitable for cGMP compliant testing of pharmaceutical glycoproteins via glycan mapping procedures (HPAEC-PAD, mass spectrometry, labeling procedures etc).

  • Up to 10 mg quantities of many of our oligosaccharide structures are available  upon request.
  • TheraProteins also supplies oligosaccharide libraries, e.g., for  recombinant antibody glycosylation mapping  (> 30 different glycan structures found in recombinant antibodies from CHO cells), cell lines and serum proteins TheraProteins also offers custom preparation of quantified glycan structure mixtures/libraries (quantified by a cGMP-certified laboratory according to a validated SOP used for GMP compliant release assays).
  • N-glycan structures are isolated from recombinant cell lines (CHO, BHK and HEK cells) or culture supernatants thereof. A combined approach using specific glycosidases and glycosyltransferases is used for preparations of some of the
    structures.
  • Purity is checked by HPAEC-PAD procedures and by ESI-MS or MALDI/TOF-MS and structural identity is confirmed by
    NMR analysis and/or MS-MS of the basic structures.
  • Apart from the N-glycans listed in the catalogue, TheraProteins offers also  custom preparation  of oligosaccharide structures for clients from the pharmaceutical industry and for research laboratories.
CONTACT US

Any questions? Our top specialists are waiting to help you!


CONTACT US